Due to the well-known “fluorine effect” of the fluorine atom and the fluorinated groups on the chemical, physical and biological properties of a given molecule, incorporation of a fluorine atom or a fluoroalkyl group into has become a routine practise in the development of drugs or agrochemicals. Consequently, development of efficient methods that could late-stage introduction of fluorine or fluorinated groups of the drug molecules have been of intense current interests and remains an unmet challenge. The Shen group tried to tackle this challenge by employing two strategies: 1) Development of electrophilic fluoroalkylating reagents; 2) Mechanism-driven new fluoroalkylating methodology discovery.