肖吉昌
肖吉昌课题组 导师介绍
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肖吉昌


研究员  博士生导师  课题组长    

电话: 021-54925340      

电子邮箱:jchxiao@sioc.ac.cn   



学历研究经历
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姓名:  肖吉昌  研究员  

电话: 021-54925340

电子邮箱:jchxiao@sioc.ac.cn  

联系地址:

上海市零陵路345号 200032 

345 Lingling Road, Shanghai, 200032, China


简介:(学习工作经历)

1988.9.-1992.7.:湖南师范大学化学系,理学学士

1992.7.-1997.7.:湖南省邵阳师范高等专科学校,讲师

1997.8.-2000.8.:上海化工研究院,工学硕士

2000.8.-2003.7.:中国科学院上海有机化学研究所,理学博士

2003.8.-2005.7.:美国爱达荷大学,博士后研究

2005.8. 至今:中国科学院上海有机化学研究所,研究员,课题组长


研究领域:中文和英文

1. 含氟功能分子的合成与反应:开发温和高效的氟化试剂,发展新颖氟化学反应,进行含氟药物分子和功能材料分子的合成

2. 绿色、高效分离纯化方法:针对组成复杂的混和物体系,发展高效分离试剂和绿色纯化方法

1. Synthesis and Reaction of Fluorine-containing Functional Molecules: Development of mild and efficient fluorination reagents; Development of novel organofluorine reactions; Synthesis of fluorine-containing pharmaceuticals, agrochemicals and functional materials 

2. Green and Efficient Separation and Purification Method: Development of efficient separation reagents and green purification process for complex mixtures 


代表性论文(工作业绩):


11. Lin, Jin-Hong; Xiao, Ji-Chang* “Fluorinated Ylides/Carbenes and Related Intermediates from Phosphonium/Sulfonium Salts” Acc. Chem. Res. 2020, 53, 1498-1510.

10. Yu, Jiao; Lin, Jin-Hong; Yu, Donghai; Du, Ruobing; Xiao, Ji-Chang* “Oxidation of difluorocarbene and subsequent trifluoromethoxylation” Nat. Commun. 2019, 10, 5362. 

9. Zhang, Min; Lin, Jin-Hong; Xiao, Ji-Chang* “Photocatalyzed Cyanodifluoromethylation of Alkenes” Angew. Chem. Int. Ed. 2019, 58, 6079-6083.

8. Zhang, Wei; Chen, Jia; Lin, Jin-Hong*; Xiao, Ji-Chang*; Gu, Yu-Cheng “Rapid Dehydroxytrifluoromethoxylation of Alcohols” iScience 2018, 5, 110-117.

7. Yu, Jiao; Lin, Jin-Hong*; Xiao, Ji-Chang* “Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines” Angew. Chem. Int. Ed. 2017, 56, 16669-16673.

6. Zheng, Jian; Cheng, Ran; Lin, Jin-Hong; Yu, Dong-Hai; Ma, Longle; Jia, Lina; Zhang, Lan; Wang, Lu; Xiao, Ji-Chang*; Liang, Steven H.* “An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18F-Labeled α-SCF3 Carbonyl Compounds” Angew. Chem. Int. Ed. 2017, 56, 3196-3200.

5. Deng, Zuyong; Lin, Jin-Hong; Xiao, Ji-Chang* Nucleophilic arylation with tetraarylphosphonium salts Nat. Commun. 2016, 7, 10337.

4. Zheng, Jian; Wang, Lu; Lin, Jin-Hong; Xiao, Ji-Chang*; Liang, Steven H.* “Difluorocarbene-Derived Trifluoromethylthiolation and [18F]Trifluoromethylthiolation of Aliphatic Electrophiles” Angew. Chem. Int. Ed. 201554, 13236-13240.

3. Zhang, Cheng-Pan; Chen, Qing-Yun; Guo, Yong; Xiao, Ji-Chang*; Gu, Yu-Cheng. “Difluoromethylation and Trifluoromethylation Reagents Derived from Tetrafluoroethane β-Sultone: Synthesis, Reactivity and Applications” Coord. Chem. Rev. 2014, 261, 28-72.

2. Zhang, Cheng-Pan; Chen, Qing-Yun; Guo, Yong*; Xiao, Ji-Chang*; Gu, Yu-Cheng “Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system” Chem. Soc. Rev. 2012, 41, 4536-4559.

1. Zhang, Cheng-Pan; Wang, Zong-Ling; Chen, Qing-Yun; Zhang, Chun-Tao; Gu, Yu-Cheng; Xiao, Ji-Chang*. “Copper-Mediated Trifluoromethylation of Heteroaromatic Compounds by Trifluoromethyl Sulfonium Salts” Angew. Chem. Int. Ed. 2011, 50, 1896-1900.


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